The victims were not immediately identified and no one else was believed to be missing, FOX 11 of Los Angeles reported.
Deer Creek is just north of Malibu along Highway 1 on the California coast.
A portion of Highway 1, the Pacific Coast Highway, is seen in California. (Associated Press)
Personnel from the Ventura County Fire Department responded to the area and a search crew recovered the victims but none survived, the report said.
A lane of Highway 1, also known as the Pacific Coast Highway, was briefly closed as authorities responded, with traffic alternating use of the remaining lane, the Ventura County Star reported.