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{"id":49098,"date":"2020-06-27T23:20:59","date_gmt":"2020-06-27T23:20:59","guid":{"rendered":"https:\/\/virusreports.net\/covid-19-may-be-linked-to-brain-complications-study-finds-but-does-it-cause-them\/"},"modified":"2020-06-27T23:20:59","modified_gmt":"2020-06-27T23:20:59","slug":"covid-19-may-be-linked-to-brain-complications-study-finds-but-does-it-cause-them","status":"publish","type":"post","link":"https:\/\/virusreports.net\/covid-19-may-be-linked-to-brain-complications-study-finds-but-does-it-cause-them\/","title":{"rendered":"COVID-19 may be linked to brain complications, study finds. But does it cause them?"},"content":{"rendered":"
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Grace Hauck<\/a>, USA TODAY<\/span>
\n Published 4:43 p.m. ET June 27, 2020 | Updated 5:01 p.m. ET June 27, 2020<\/span><\/span><\/p>\n<\/section>\n

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Dr. Anthony Fauci speaks to how personal responsibility and social distancing is the key to ending the spread of the coronavirus.<\/p>\n

USA TODAY<\/span><\/p>\n<\/div>\n<\/div>\n

A new study has found further evidence of a correlation between severe cases of COVID-19 and\u00a0brain complications, but researchers say they still aren’t sure whether those complications are directly caused by the disease.<\/p>\n

The preliminary study, billed as the first nationwide survey of the neurological complications of the disease<\/a>, was published in The Lancet Psychiatry this week.<\/p>\n

Over the course of three weeks in April, researchers surveyed 153 hospitalized patients in the U.K. who had both a new confirmed or probable COVID-19 diagnosis and a new neurological or psychiatric diagnosis.<\/p>\n

Researchers found that, among the 125 patients with complete medical records, 57 had a stroke caused by a blood clot in the brain and 39 had an altered mental state. Among the patients with an altered mental state, 10\u00a0of the patients had developed psychosis\u00a0\u2013 a “break with reality”\u00a0\u2013\u00a0and seven\u00a0had\u00a0encephalitis, or\u00a0inflammation of the brain.<\/p>\n

The patients ranged from 23 to 94 years old. While strokes were more common in older patients, researchers reported that patients experienced\u00a0an altered mental state across age groups.<\/p>\n

“Whilst an altered mental state was being reported by some clinicians, we were surprised to identify quite so many cases, particularly in younger patients, and by the breadth of clinical syndromes,” Dr. Benedict Michael, who led the study for the University of Liverpool, said in a press release.<\/p>\n

The study, though small, helps paint a larger picture of the many types of neurological effects of COVID-19,\u00a0said Dr. Babak Jahromi, a neurosurgeon at Northwestern Medicine.<\/p>\n

“While we\u2019ve learnt over the past few months that hospitalized COVID-19 patients have a higher risk of suffering ischemic strokes, the current study adds to that picture by also showing neuropsychiatric disorders in hospitalized COVID-19 patients,” Jahromi said.<\/p>\n

The study is the most recent in more than 300 published works looking into a possible connection between COVID-19 and neurological conditions. Several of the studies, including one in China<\/a> and one in France<\/a>, found that coronavirus patients frequently reported neurological symptoms. In other reports, autopsies on coronavirus patients in Germany found inflammation in the brain<\/a>, and autopsies on patients in Massachusetts\u00a0detected\u00a0low levels of the virus in the brain<\/a>.<\/p>\n

In the U.S., news of a possible link between severe COVID-19 and brain complications gained momentum in April, when New York City doctors reported\u00a0a surge in strokes in younger patients<\/a>. Over a two-week period, Mount Sinai doctors reported five patients under the age of 50 who suffered large vessel strokes, according to a letter they published in the New England Journal of Medicine.<\/p>\n

Given the prevalence of the coronavirus worldwide, it’s possible that the correlation between severe COVID-19 and brain complications is merely coincidental, said Dr. Robert Stevens, who specializes in neurological critical care at Johns Hopkins Medicine.<\/p>\n

“We’re seeing this interesting association, but it\u2019s very difficult to say, based on this type of result, that COVID causes or explains these neurological symptoms,” Stevens said. Especially with regard to the patients that developed psychosis, “it’s really, really important, especially in these times when people are living in isolation and social distancing, there are plenty of reasons for people to lose it.”<\/p>\n

Stevens said the new Lancet study was valuable in that it marks the first systematic effort to characterize neurological and psychiatric conditions in patients with confirmed or suspected COVID-19.\u00a0It also sparks more questions\u00a0for future studies, Stevens said. Who is most susceptible to neurological or psychiatric complications? If the coronavirus is causing brain complications, how is that happening \u2013 through direct invasion of the cells, or by triggering a harmful, inflammatory immune response?<\/p>\n

If the coronavirus does cause\u00a0brain complications, that wouldn’t be surprising, Stevens said.\u00a0Other viral diseases, such as Zika and HIV, are also known to cause brain complications. Several studies have also documented that diseases caused by other coronaviruses\u00a0\u2013\u00a0Severe Acute Respiratory Syndrome and\u00a0Middle East Respiratory Syndrome\u00a0\u2013 caused brain complications.<\/p>\n

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“It would not be unexpected,” Stevens said. “But I think that\u2019s going to turn out to be a relatively rare occurrence.”<\/p>\n

Stevens said he and his team\u00a0at Johns Hopkins are\u00a0working with\u00a080 sites worldwide to enroll patients in an observational study on the effects of COVID-19 over time.<\/p>\n

“If there is indeed a link between COVID and serious complications like stroke and brain hemorrhage, the bigger question is \u2013 what are the longer-term effects?” he said. “In the next six\u00a0to 12 months, we should know a lot more.”<\/p>\n

The authors of the study said their work should alert clinicians to the possibility of patients with COVID-19 developing neurological and psychiatric complications.<\/p>\n

Follow Grace Hauck on Twitter at @grace_hauck<\/a>.<\/em><\/p>\n

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