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]]>COVID-19 triggered changes in blood platelets could be a contributing factor to the onset of heart attacks and strokes in some patients with the disease, new research reveals.
Scientists from the University of Utah Health found that inflammatory proteins produced during infection significantly alter the function of platelets, making them “hyperactive” and more prone to form dangerous and potentially deadly blood clots.
Researchers hope that if they can better understand the causes of these changes, they could lead to more effective treatments for patients. Their report appears in Blood, an American Society of Hematology journal.
“Our finding adds an important piece to the jigsaw puzzle that we call COVID-19,” said Robert A. Campbell, senior author of the study and an assistant professor in the Department of Internal Medicine, in a statement. “We found that inflammation and systemic changes, due to the infection, are influencing how platelets function, leading them to aggregate faster, which could explain why we are seeing increased numbers of blood clots in COVID patients.”
According to scientists, some evidence suggests that COVID-19 is associated with an increased risk of blood clotting, which can lead to other cardiovascular problems in some patients.
Researchers studied 41 COVID-19 patients hospitalized at University of Utah Hospital in Salt Lake City; next, they compared blood from these patients with samples taken from healthy individuals who were matched for age and sex.
COVID-19’S IMPACT DOCUMENTED BY SATELLITE IMAGERY IN NEW INITIATIVE FROM US, JAPAN AND EUROPE
The researchers found that SARS-CoV-2, the virus that causes COVID-19, seems to trigger genetic changes in platelets. Those changes also impact how platelets interacted with the immune system, likely contributing to respiratory inflammation that could result in more severe lung injury.
“There are genetic processes that we can target that would prevent platelets from being changed,” Campbell explained. “If we can figure out how COVID-19 is interacting with megakaryocytes or platelets, then we might be able to block that interaction and reduce someone’s risk of developing a blood clot.”
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]]>The post Seattle CHOP zone prompts lawsuit from businesses, residents: reports appeared first on Virus Reports.
]]>Numerous Seattle businesses – including an auto repair shop, a tattoo parlor and a property management company – sued the city Wednesday, alleging city officials were complicit in allowing an “occupied protest” that has made them feel unsafe in their neighborhood, according to reports.
Workers and residents also joined the lawsuit over CHOP, the Capitol Hill Occupied Protest, which drew scorn from President Trump and other critics who accused Mayor Jenny Durkan, the city’s police chief and other city leaders of turning the area over to “anarchists.”
Organizers of CHOP — part of the widespread rioting and demonstrations that followed the May 25 death of George Floyd in police custody in Minneapolis — said they sought to establish a “police-free” area in Seattle’s Capitol Hill district.
SEATTLE CHOP LEADERS URGE PROTESTERS TO GO HOME, THROW SUPPORT BEHIND BIDEN, DEMOCRATS
Since the occupation began June 8, the area has seen shootings, vandalism and other crimes.
Last Sunday a 17-year-old victim was shot in an arm and last Saturday a 19-year-old man was shot dead and another person was critically wounded, Q13 FOX of Seattle reported. In both cases, hostile crowds slowed police efforts to reach the crime scenes, the station’s report said.
“(T)his lawsuit is about the constitutional and other legal rights of plaintiffs – businesses, employees and residents in and around CHOP – which have been overrun by the city of Seattle’s unprecedented decision to abandon and close off an entire city neighborhood, leaving it unchecked by the police, unserved by fire and emergency health services and inaccessible to the public at large,” the lawsuit says, Q13 FOX reported.
One local business owner, Joey Rodolfo of Buki clothing, told “Fox & Friends” this week that he plans to move out of state because of what he described as Seattle’s lack of governmental leadership.
“Since we have no leadership and we have a city council that’s so socialist, there really is very, very little support for businesses,” Rodolfo said. “As far as the city reaching out to small businesses like ourselves, or any business, there has been zero.”
The Seattle city attorney’s office told local media that it hadn’t yet had an opportunity to review the lawsuit but planned to respond after reviewing it.
The plaintiffs allege that city leaders provided the demonstrators with barriers, public restrooms and medical supplies – in effect supporting the occupation of the neighborhood and hindering the efforts of local businesspeople, employees and residents to reach their buildings, receive deliveries and provide services, the Seattle Times reported.
The CHOP zone has also worsened conditions for elderly and disabled people in the area, the lawsuit asserts, according to the newspaper.
“The result of the City’s actions has been lawlessness,” Calfo Eakes LLP, the law firm representing the plaintiffs, told the Times in a statement. “There is no public safety presence. Police officers will not enter the area unless it is a life-or-death situation, and even in those situations, the response is delayed and muted, if it comes at all.”
“The result of the City’s actions has been lawlessness.”
— Calfo Eakes LLP, law firm representing plaintiffs suing Seattle
Facing mounting pressure, Durkan on Monday said the city would begin dismantling the blocks-long occupied area – claiming the crimes and other violence in the zone were distracting from the message that peaceful protesters tried to communicate when they established the occupation, Q13 FOX reported.
“The cumulative impacts of the gatherings and protests and the nighttime atmosphere and violence has led to increasingly difficult circumstances for our businesses and residents,” Durkan said. “The impacts have increased and the safety has decreased.”
CLICK HERE TO GET THE FOX NEWS APP
Soon after the occupation began, President Trump told Fox News’ Harris Faulkner that he thought Durkan and Washington state Gov. Jay Inslee had surrendered control of the situation.
“I will tell you, if they don’t straighten that situation out, we’re going to straighten it out,” Trump said June 11, in an interview that aired on “Outnumbered Overtime” in its entirety the next day.
In a social media message posted Wednesday, addressed to “Comrades in the struggle,” CHOP organizers declared their “project” concluded, and urged demonstrators to leave by Wednesday night.
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]]>The post Pandemic Prompts Fears That Viruses Buried In Permafrost Will Come Back To Life As Arctic Warms : Goats and Soda appeared first on Virus Reports.
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Editor’s note: There’s been speculation on the media and via Twitter that DNA fragments of the now-defunct 1918 flu pathogen could be preserved under the permafrost and might pose a potential threat to humans if the warming Earth continues to melt layers of frozen soil. A few years ago, we investigated that question: Could this pathogen — and others — be revived?
Last summer, Zac Peterson was on the adventure of a lifetime.
The 25-year-old teacher was helping archaeologists excavate an 800-year-old log cabin, high above the Arctic Circle on the northern coast of Alaska.
They had pitched tents right on the beach. Over the course of a month, Peterson watched a gigantic pod of beluga whales swim along the beach, came face-to-face with a hungry polar bear invading their campsite and helped dig out the skull of a rare type of polar bear.
But the most memorable thing happened right at the end of the trip.
“I noticed a red spot on the front of my leg,” Peterson says. “It was about the size of a dime. It felt hot and hurt to touch.”
The spot grew quickly. “After a few days, it was the size of a softball,” he says.
Peterson realized he had a rapidly spreading skin infection. And he thought he knew where he might have picked it up: a creature preserved in the permafrost.
Nano-zombies or red herrings?
In the past few years, there has been a growing fear about a possible consequence of climate change: zombie pathogens. Specifically, bacteria and viruses — preserved for centuries in frozen ground — coming back to life as the Arctic’s permafrost starts to thaw.
The idea resurfaced in the summer of 2016, when a large anthrax outbreak struck Siberia.
A heat wave in the Arctic thawed a thick layer of the permafrost, and a bunch of reindeer carcasses started to warm up. The animals had died of anthrax, and as their bodies thawed, so did the bacteria. Anthrax spores spread across the tundra. Dozens of people were hospitalized, and a 12-year-old boy died.
On the surface, it looked as if zombie anthrax had somehow come back to life after being frozen for 70 years. What pathogen would be next? Smallpox? The 1918 flu?
The media took the idea of “zombie pathogens” and ran with it.
“Climate change … could awaken Earth’s forgotten pathogens,” The Atlantic wrote in November. “Many of these pathogens may be able to survive a gentle thaw — and if they do, researchers warn, they could reinfect humanity.”
“Scientists are witnessing the theoretical turning into reality: infectious microbes emerging from a deep freeze,” Scientific American wrote.
But something is a little fishy about these “zombie pathogen” stories: The evidence presented is as holey as Swiss cheese.
The key researcher cited is a biologist who studies amoeba viruses, not human viruses. These so-called monster viruses have evolved to live in cold soil, deep underground, not in warm, human flesh above ground.
And in terms of zombie bacteria, anthrax is a red herring. Anthrax has been “rising up” from soils all over the world for millennia, even longer. The bacteria survive by hibernating in the ground until conditions are right and then spring back to life. Back in the Middle Ages, it was common to see fields of dead sheep in Europe, wiped out by “zombie” anthrax. The French called these fields champs maudits, or the “cursed fields.”
Now there are some tantalizing hints that the Arctic is, indeed, a frozen champ maudits, filled with pathogens even more dangerous than anthrax. Across the permafrost — which covers an area twice the size of the U.S. — there are tens of thousands of bodies preserved in the frozen soil. Some of these people died of smallpox. And some died of the 1918 flu — a strain of influenza that swept the globe and killed more than 50 million people.
But is there actually any evidence that these deadly viruses could survive a “gentle thaw” and then start a new outbreak?
To figure that out, I headed up to the top of the world, where Zac Peterson was last summer, to see exactly what type of creatures — and diseases — are hiding in the permafrost.
I was not disappointed.
“We’ve got a head right here”
Up on top of an ocean bluff, Zac Peterson and a few students are on their knees, digging inside a hole that’s about the size of a Volkswagen minivan.
In 2013, a severe storm ripped off a big chunk of the bluff. Now the 800-year-old cabin is teetering on the edge of a cliff, near the town of Utqiagvik in Alaska. The team is trying to pull off an emergency excavation before the cabin crumbles into the ocean.
A team of volunteers is rushing to excavate an ancient hunting cabin near Utqiagvik, Alaska, the town formerly known as Barrow.
Zachary Peterson
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Zachary Peterson
Hunters have been using this spot for thousands of years. At one end of the house, somebody was storing fresh kills.
“We’ve got a head right here, and a main body right there,” says Peterson, as he points to two mummified seals, lying face up in a soup of thawing permafrost and decaying sea mammal flesh inside the cabin.
The seals are starting to warm up. Their organs are seeping out of their bodies and beginning to decay. The whole area smells like a rotting tuna fish sandwich. Peterson’s pants are covered in black, oily goo.
In the past few years, severe storms have ripped off big chunks of the Alaska coastline. The white bags are used to try to prevent the ancient log cabin from sliding into the sea.
Zachary Peterson
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Zachary Peterson
The seals have been buried in permafrost for about 70 years. They are incredibly well-preserved. You can see their skin, their whiskers and even something that looks like a flipper.
“That’s what’s so amazing about Arctic sites,” says Anne Jensen, an archaeologist with the Ukpeavik Iupiat Corp. who is leading the excavation. “The preservation is amazing,” she says. “It’s like the animal just keeled over and died right then.”
Then something even creepier appears in the ice: a human molar.
“It’s just a tooth,” Jensen says. “People lose them all the time. And then just throw them out.”
Now, this hunting cabin isn’t built on a burial ground. Jensen doesn’t think any bodies are buried near here. But Jensen is a world expert on excavating human remains from Arctic permafrost.
“I’ve probably dug up as many burials as anybody, ” she says. “I would prefer not to be excavating burials. But I’ve spent a lot of my career doing that.”
She has excavated everything from individual body parts — one time, she found just an upper arm in the ice, she says — to a massive cemetery, right here along the coast.
In the late 1990s, the graves in the cemetery started washing into the sea because this stretch of the Alaska coast is eroding. The local government called Jensen in to save the bodies. She saved dozens. But a few hundred remain, threatened by erosion.
Sometimes these mummified human bodies — which can be centuries old — are just as well-preserved as the seals in the log cabin, Jensen says.
“The little frozen girl from Uquitavik, she was actually better preserved than the seals,” Jensen says. “She was about the age my daughter was at the time, so it was really sad.”
Buried in the meat cellar with a little sled
Back in 1994, erosion exposed the body of a 6-year-old girl completely encased in ice for about 800 years. “Water had seeped into her burial,” Jensen says. “So we took her out as a block of ice.”
The little girl was carefully wrapped in a duck-skin parka with a fur-trimmed collar. Her parents had buried her with a little sled inside their meat cellar.
Her body was so well-preserved that Jensen shipped her to Anchorage so doctors could do a full autopsy. One of those doctors was Michael Zimmerman, a paleopathologist at the University of Pennsylvania who has been studying mummified bodies for 30 years.
“When you open up frozen bodies from Alaska, all the organs are right in place and easily identified,” Zimmerman says. “It’s not like Egyptian mummies where everything is shrunk and dried up.”
Doctors can easily see why a person died. For the little frozen girl, it was starvation. But Zimmerman has seen infections in bodies excavated from permafrost. In one case, a mummy from the Aleutian Islands seemed to have died of pneumonia. When Zimmerman looked for the bacteria inside the body, there they were, frozen in time.
“We could see them under the microscope, inside the lungs,” Zimmerman says.
But were these “zombie” bacteria? Could they come back to life and infect other people? Zimmerman tried to revive the bacteria. He took a smidge of tissue from the lungs. Warmed it up. Fed it.
“But nothing grew,” Zimmerman says. “Not a single cell.”
Zimmerman says he wasn’t surprised the bacteria were dead. Pneumonia bacteria have evolved to live in people at body temperature, not cold soil.
“We’re dealing with organisms that have been frozen for hundreds of years,” he says. “So I don’t think they would come back to life.”
But what about viruses — like smallpox or the 1918 flu? “I think it’s extremely unlikely,” Zimmerman says.
In 1951, a graduate student decided to test this out. Johan Hultin went to a tiny town near Nome, Alaska, and dug up a mass grave of people who had died of the 1918 flu.
He cut out tiny pieces of the people’s lungs and brought them back home. Then he tried to grow the virus in the lab.
“I had hoped that I would be able to isolate a living virus,” Hultin told NPR in 2004. “And I couldn’t. The virus was dead.
“In retrospect, maybe that was a good thing,” Hultin added.
A good thing, yes. But here’s the disturbing part. Hultin tried to capture the 1918 flu virus again, 45 years later.
By this time he was a pathologist in San Francisco. He heard scientists were trying to sequence the virus’s genome. So at age 73, Hultin went back to Alaska. And he took a piece of lung from a woman he named Lucy.
“Using his wife’s pruning shears, Hultin opened Lucy’s mummified rib cage. There he found two frozen lungs, the very tissue he needed,” the San Francisco Chronicle reported.
“Her lungs were magnificent, full of blood,” Hultin told the paper.
At the same time, a Canadian team of scientists went hunting for the 1918 flu virus in Norway. They dug up seven bodies. But none of them were frozen, and the team failed to recover any virus particles.
In the 1990s, Russian scientists intentionally tried to revive smallpox from a body in their permafrost. They recovered pieces of the virus but couldn’t grow the virus in the lab.
All these attempts — and all these failures — make you wonder: Maybe it isn’t melting permafrost we should worry about when it comes to zombie pathogens, but what scientists do in the lab.
It’s not over until the fat seal sings
When I finished writing this story in December, I ended it with a faint warning about the dangers of human curiosity. I was convinced that the only way “pathogens” would rise up from the permafrost was if a scientist bent over backward to resurrect the creatures in the lab. The chance of it happening naturally seemed infinitesimally small.
But then I received an email from Zac Peterson: “After kneeling in defrosted marine mammal goo … doctors treated me for a seal finger infection,” Peterson wrote. A photo showed a purplish-red infection covering the front of his knee.
Seal finger is a bacterial infection that hunters contract from handling the body parts of seals. The infection can spread rapidly into the joints and bones. Sometimes people lose fingers and hands.
The doctors never tested Peterson’s infection to see if it really was seal finger. It responded well to simple antibiotics — the treatment for seal finger.
The only seals Peterson had handled were those in the log cabin. Those seals had been frozen in permafrost for decades.
“Even if there’s a possibility it was something else,” Peterson wrote, “I still tell people that I got infected by an 800-year-old strain of a seal hunter’s disease that was trapped in ice.”
Peterson just might be the first victim of “zombie bacteria” rising from Alaska’s thawing permafrost.
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