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A study looks at the impact of having both hearing and vision impairment on the chances of developing dementia.

senior woman looking downwards — New research suggests that a dual sensory impairment significantly raises the chances of developing dementia.

Researchers have linked hearing impairment and vision impairment individually to an increased chance of developing dementia. However, a new study finds that an individual’s chances of developing dementia are significantly higher when they have both conditions.

The risk of developing dementia increases by 86% for individuals who have both hearing and visual impairment.

“Evaluation of vision and hearing in older adults may predict who will develop dementia and Alzheimer’s. This has important implications for identifying potential participants in prevention trials for Alzheimer’s disease, as well as whether treatments for vision and hearing loss can modify risk for dementia.”

– Study lead author Phillip H. Hwang, University of Washington

The research, “Dual sensory impairment in older adults and risk of dementia from the GEM Study,” appears in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring.

According to the study, some 33% of people aged 70 and older experience hearing loss, and vision loss affects about 18% of people in this age group. Since these conditions worsen with age, researchers think that a correlation exists between the advance of these conditions and the loss of a person’s functionality and mortality.

Previous research found a less obvious connection between hearing or visual loss and the onset of dementia.

The two leading theories indicate that either these specific impairments result from similar physical processes that cause dementia, or that hearing and visual loss lead to an increasing sense of social isolation, depression, and physical inactivity, each of which may lead to dementia.

The new study looks at the impact of having both conditions together. It refers to this combination as “dual sensory impairment.” According to the study:

“Although most prior studies have focused on impairments in hearing and vision individually, the impact of having combined hearing and visual impairment, or dual sensory impairment (DSI), on dementia risk is unclear.”

To investigate the impact of DSI on developing dementia, the researchers analyzed data collected by the Gingko Evaluation of Memory (GEM) study, a double‐blind randomized‐controlled trial investigating the value of Ginkgo biloba for preventing dementia in older people.

The GEM study involved adults aged 75 or older who, at the outset of the study, had normal cognitive function, or at most, mild dementia. The researchers studied the participants for 8 years.

In addition to collecting self-reported data regarding the individuals’ hearing and vision, follow-up examinations of participants assessed the development of dementia.

The final data set that Hwang and his colleagues studied consisted of 2,051 individuals. Of these, 1,480 people had neither hearing nor visual loss. 14.9% reported visual impairment, and 7.8% reported hearing loss. Just 5.1%, or 104 individuals, had DSI.

Compared to participants who did not have hearing or visual loss, those reporting DSI were more likely to be male, have other comorbidities, and describe themselves as smokers and drinkers.

The GEM study’s follow-up examinations revealed the following likelihoods of developing dementia:

14.3% of those without any reported hearing or vision loss developed dementia.
16.9% of those reporting a single impairment developed dementia.
28.8% of those with DSI developed dementia.

People with both hearing and visual loss were nearly twice as likely to develop dementia as those without such impairments.

However, according to the results, the increased risk of dementia for an individual with DSI is only somewhat related to the severity of hearing and visual impairment.

While those classified as having a high level of DSI are at the greatest risk of developing dementia, those with lower DSI levels also have a significantly higher risk of dementia.

The researchers analyzed the link between DSI and three types of dementia: all-cause dementia, Alzheimer’s-related dementia, and vascular dementia.

The chances of acquiring Alzheimer’s’-related dementia are even higher. The study indicated that people with DSI are 112% more likely to develop Alzheimer’s than those without any impairment.

Hwang and his colleagues found no association between DSI and vascular dementia.

The study’s conclusions suggest that doing more to mitigate hearing and visual loss in older people may be a way to hold off or thwart the onset of dementia.

The authors conclude, “Further research is needed to characterize the exact role of sensory impairments and whether treatments that improve sensory function, such as surgery or sensory aids, devices, and prostheses, can modify this risk.”

The study’s authors add that shifts toward an older general population make addressing the prevalence of dementia in the elderly more urgent.

They write: “Because the public health burden of dementia will increase over the next three decades, evaluation of vision and hearing function in older adults may help identify patients at elevated risk of developing dementia.”

Scientists have discovered a way to track changes in sound processing in the brains of people with HIV. Their test provides a simple technique for studying how HIV affects the central nervous system.

Scalp electrodes to monitor brain activity — By measuring brain signals, researchers have observed the impact of HIV on the central nervous system.

Due to advances in antiretroviral drug treatment over the past 20 years, most people with HIV can now expect to live long, healthy lives.

However, even if treatment successfully brings the virus under control, people can experience cognitive issues as a result of HIV causing damage to their central nervous system.

Up to 45% of people with HIV may develop these difficulties, which are known collectively as HIV-associated neurocognitive disorder (HAND).

Although the cause of HAND remains unknown, scientists have several theories. They speculate, for example, that it may be the result of chronic inflammation, lingering damage from the initial infection, or a toxic effect of antiretroviral drugs.

Alternatively, low levels of the virus may persist in the brain as a result of the blood-brain barrier limiting the passage of antiretroviral drugs into the brain.

The signs and symptoms of HAND can be subtle, which makes it challenging for doctors to diagnose early and monitor.

One of the problems that people with HIV sometimes report is difficulty understanding speech in the presence of background noise.

Researchers at the Geisel School of Medicine at Dartmouth in Hanover, NH, led a team that studied the hearing of a group of people with HIV in Dar es Salaam in Tanzania.

They collaborated with scientists from the Muhimbili University of Health and Allied Sciences in Dar es Salaam and neuroscientists from Northwestern University in Evanston, IL.

“Initially, we thought we’d find that HIV affects the ear, but what seems to be affected is the brain’s ability to process sound,” says study co-leader Dr. Jay Buckey Jr., a professor of medicine at Geisel.

To test this idea, they used scalp electrodes to monitor the brain waves of 68 people with HIV and 59 people without as they listened to sounds.

Specifically, they recorded a brain response known as the speech-evoked frequency-following response (FFR).

Certain features of brain waves, such as their timing and amplitude, reveal how faithfully the brain encodes an auditory stimulus. The FFR has proven particularly useful for investigating how the brain processes information in highly complex sounds, such as music and speech.

The precision and accuracy of the FFR can improve as a result of experience, such as in trained musicians, or worsen as a result of illness or damage, such as concussion.

“There are many acoustic ingredients in speech, such as pitch, timing, harmonics, and phrase,” says study co-leader Nina Kraus, Ph.D., a professor of communication sciences and neurobiology at Northwestern.

“The FFR enables us to play speech sounds into the ear of study participants and figure out how good a job the brain is doing processing these different acoustic ingredients.”

The researchers recorded the FFR while the study participants listened to common speech sounds, such as “ba,” “da,” and “ga.”

They looked at how well the signal encoded two acoustic features of speech, known as the harmonics corresponding to the first formant and fundamental frequency.

The harmonics corresponding to the first formant identify the units of sound, or “phonemes,” that differentiate one word from another, whereas the fundamental frequency reflects the frequency at which the vocal cords vibrate, which helps identify the speaker.

The brains of people with HIV had similar responses to the brains of people without HIV at processing the fundamental frequency.

They also performed well on standard tests of hearing, but the FFR revealed that the brains of people with HIV were worse at encoding the first formant.

In other words, they had normal hearing thresholds, but their brains could not distinguish between the sounds of different words as accurately.

“When the brain processes sound, it’s not like a volume knob where all of the acoustic ingredients are either processed well or poorly,” Kraus explains. “With the FFR, we’re able to see which aspects of auditory processing are affected or diminished and ask, ‘[I]s there a specific neural signature that aligns itself with HIV?’”

The researchers have published their study in the journal Clinical Neurophysiology.

The researchers note that as people get older, even if their hearing remains normal, their brains get worse at processing the same speech features that the brains of people with HIV seem to struggle with.

They write that HIV-associated cognitive problems may therefore be akin to early aging.

In the future, they hope that other scientists will use the FFR not only to study brain dysfunction associated with HIV, but also other conditions, such as concussion and Alzheimer’s disease.

Standard tests of cognitive function involve giving people tasks, such as solving math problems or remembering a list of words. However, these are dependent on the language people speak and their culture.

“What’s significant about our results is that the test doesn’t require any actions on the [subject’s] part. It’s recorded passively — subjects can even sleep or watch a movie,” says Dr. Buckey. “We think the FFR holds a lot of promise as a way to assess the brain easily and objectively.”

In their paper, the researchers note that the test could prove particularly useful in parts of the world with the most HIV infections and limited healthcare resources.

They write, “While previous neuroimaging and electrophysiological studies have shown differences between HIV+ and HIV- individuals, these approaches are difficult to transport to resource-limited settings such as sub-Saharan Africa, where >70% of the world’s HIV+ population lives and where there is some evidence that neurocognitive symptoms are more severe.”

“Thus, the FFR holds promise as a research tool to further study [central nervous system] health, particularly in resource-limited settings.”

The study authors acknowledge that research projects involving more participants will be necessary to confirm their results. They say that it would also be interesting to track changes in the FFR from the early stages of infection onward.

Finally, in light of evidence suggesting that different strains of the virus may have differing neurological effects, they would like to see studies that compare FFR tests in different populations around the world.

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