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https://s3.us-west-1.wasabisys.com/virusreports/2020/05/cropped-virus-favicon-32x32.png Groundbreaking Archives - Virus Reports https://virusreports.net/tag/groundbreaking/ 32 32 Groundbreaking blood test can detect cancer years before symptoms appear https://virusreports.net/groundbreaking-blood-test-can-detect-cancer-years-before-symptoms-appear/ https://virusreports.net/groundbreaking-blood-test-can-detect-cancer-years-before-symptoms-appear/#respond Mon, 27 Jul 2020 13:20:59 +0000 https://virusreports.net/groundbreaking-blood-test-can-detect-cancer-years-before-symptoms-appear/ Developed by a Sino-US startup, the groundbreaking new blood test is referred to as PanSeer. blood test 521 (photo credit: BIOMEDICAL ENGINEERING, TECHNION) A new blood test can detect various types of cancer years before previously possible with traditional detection methods, according to a new research published in the scientific journal Nature Communications. Early detection…

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Developed by a Sino-US startup, the groundbreaking new blood test is referred to as PanSeer.

blood test 521 (photo credit: BIOMEDICAL ENGINEERING, TECHNION)

blood test 521

(photo credit: BIOMEDICAL ENGINEERING, TECHNION)

A new blood test can detect various types of cancer years before previously possible with traditional detection methods, according to a new research published in the scientific journal Nature Communications.

Early detection of cancer has the potential to significantly decrease death rates caused by the disease. Scientists have tried for years to develop a cancer screening-test that would reliably detect malignancy potential before tumor cells have the chance to spread, making treatment more effective. But until today, most attempts were unsuccessful or had partial results at best.  

Developed by a Sino-US startup, the groundbreaking new blood test is referred to as PanSeer. It was developed by an international team of scientists at the University of California, who were successfully able to diagnose five different types of cancer long before symptoms appeared in the patients it tested.

The five types of cancer that PanSeer can currently detect are stomach cancer, esophageal cancer, bowel cancer, lung cancer and liver cancer, all fairly common.

The test is based on a technique that was developed over a decade and allows detection of malignant tumors in their early stages, which haven’t led to any symptoms yet and were thus undetectable with previous methods.

Previous detections methods typically involved researchers collecting blood samples from people already diagnosed with the disease.

The new study on the other hand, included a 10-year health survey conducted between 2007-2017 that took blood samples from more than 120,000 healthy people in China, collecting samples from people before they had presented any signs of having cancer.

The detection technique is based on a biological process called DNA methylation analysis, which screens for DNA signatures specific to different cancers and identifies locations that have the greatest chance of signaling the presence of cancer. A special algorithm then compiles the findings and presents an indication of a person’s likelihood of developing the disease.     

“What we showed is: up to four years before these people walk into the hospital, there are already signatures in their blood that show they have cancer,” says Kun Zhang, a bioengineer at the University of California, San Diego, and a co-author of the study. “That’s never been done before.”

The test managed to detect early signs of cancer in 95% of the 605 patients who didn’t show any symptoms when being tested but developed cancer up to four years later.

The researchers hope that PanSeer or a similar blood test will become a standard annual test but noted that further and more comprehensive studies need to be done before that can happen.

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E.U. Adopts Groundbreaking Stimulus to Fight Coronavirus Recession https://virusreports.net/e-u-adopts-groundbreaking-stimulus-to-fight-coronavirus-recession/ https://virusreports.net/e-u-adopts-groundbreaking-stimulus-to-fight-coronavirus-recession/#respond Tue, 21 Jul 2020 19:22:20 +0000 https://virusreports.net/e-u-adopts-groundbreaking-stimulus-to-fight-coronavirus-recession/ The $857 billion package includes unprecedented steps to help less wealthy countries, including selling collective debt and giving much of the money as grants, not loans.European leaders were tasked with negotiating a proposed 750 billion euro ($860 billion) rescue package to support member countries dealing with the economic collapse caused by the pandemic.Credit...Pool photo by…

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The $857 billion package includes unprecedented steps to help less wealthy countries, including selling collective debt and giving much of the money as grants, not loans.

Credit…Pool photo by Francisco Seco

Matina Stevis-Gridneff

BRUSSELS — After nearly five days of intense haggling, European Union leaders early on Tuesday stepped up to confront one of the gravest challenges in the bloc’s history, agreeing to a landmark spending package to rescue their economies from the ravages of the pandemic.

The 750 billion euro ($857 billion) stimulus agreement, spearheaded by Chancellor Angela Merkel of Germany and President Emmanuel Macron of France, sent a strong signal of solidarity even as it exposed deep new fault lines in a bloc reshaped by Britain’s exit.

The deal was notable for its firsts: European countries will raise large sums by selling bonds collectively, rather than individually; and much of that money will be handed out to member nations hit hardest by the pandemic as grants that do not have to be repaid, and not as loans that would swell their national debts.

Those extraordinary steps reflected a difficult consensus among members: that the scale of the crisis facing them required groundbreaking measures to ensure the bloc’s legitimacy, stability and prosperity.

“Europe has shown it is able to break new ground in a special situation. Exceptional situations require exceptional measures,” Ms. Merkel said in a news conference at dawn. ‘‘A very special construct of 27 countries of different backgrounds is actually able to act together, and it has proven it.”

But the lengthy negotiations in Brussels were notable, too, for their exceptional rancor — and it was clear that the pooling of resources and sovereignty had come at a cost.

A strange kind of political theater, never visited upon European Union summits before, marked the meeting — with leaders donning masks and bumping elbows to greet. They were safely spaced in a vast hall, their entourages trimmed to only the most essential members.

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Credit…Pool photo by John Thys

When they convened on Friday, it was their first in-person summit in the five months since the coronavirus took hold in Europe. The meeting was officially scheduled to last until Saturday. By Monday morning, exhausted and angry after bargaining all night, they were still tussling over the details. The start of Monday’s session was twice delayed, and then it spilled into Tuesday morning.

As negotiations broke down over the weekend, so did many precautions the leaders and their teams had taken to protect themselves from the virus, which in most of Europe has been brought down to manageable levels, in any case. As the hours wore on and the talks grew heated, the diplomatic gloves came off, and so did the masks. Breakout groups met in rooms far smaller and less ventilated than the 300-seat auditorium where the general meeting was convened.

While there is no underestimating the importance of the agreement — the generosity of its size and the novelty of its mechanisms — the acrimony and dramatics of the four-day meeting betrayed the new divisions within the bloc. They also signaled where the fractures may lie in future crises.

The talks were defined by shifting roles among members now jostling to make their voices heard and for leadership in the absence of Britain, which had often played the part of the thrifty contrarian, fastidious about rules, in past summits.

This time, Ms. Merkel, unusually for a German leader, and holding the E.U.’s rotating presidency, put her finger on the scale on behalf of hard-hit southern countries and did battle with the nations she once championed, the northern members that have been less affected by the virus and are wary of the vast sums being thrown around.

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Credit…Pool photo by Francisco Seco

Where Friday’s meeting was marked by joyful greetings and even celebrations of the birthdays of two leaders — Ms. Merkel, now 66, and Prime Minister Antonio Costa of Portugal, who turned 59 — Sunday night’s dinner (a “cold dish” after several sumptuous meals, socially spaced but unmasked) was marked by shouting matches and a nasty atmosphere.

Mr. Macron, for example, yelled at Chancellor Sebastian Kurz of Austria for not only being a tightfisted impediment to the rescue deal but also for leaving the room to take a call. To some leaders’ shock, the French president slapped the table. Mr. Kurz tried to keep his cool, and in a zinger put Mr. Macron’s temper tantrum down to sleep deprivation, diplomats said.

As that meeting broke up without a deal around 6 a.m. Monday, Mark Rutte, the Dutch prime minister, told his country’s media that he didn’t care if other leaders mockingly called him “Mr. No” for blocking the agreement. (They did.)

“We’re here because everyone is taking care of their own country, not to go to each other’s birthdays for the rest of our lives,” he said bluntly.

It was Mr. Rutte who stepped into the vacuum left by Germany’s shift and Britain’s departure to lead the so-called Frugal Four, which include his nation as well as Austria, Sweden and Denmark. Occasionally, the “frugals” became five with the support of Finland.

In the end, with a unanimous decision by the 27 nations needed for a plan to go forward, a bitter compromise prevailed. The ambitious plan pushed by Ms. Merkel and Mr. Macron was watered down, but remained significant. The overall figure of €750 billion remained, but an original proposal to offer €500 billion of that in the form of grants was trimmed back to €390 billion, with €360 billion earmarked for loans.

In addition to raising cash and extending grants, the package will increase lending and deploy other, more traditional stimulus methods to arrest and reverse the economic free-fall that threatens the stability of the world’s richest bloc of nations.

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Credit…Pool photo by Francisco Seco

Economists predict a recession far worse than anything since World War II. France, Italy and Spain, the bloc’s second-, third- and fourth-largest economies, are expected to suffer the most, clocking in contractions of around 10 percent this year.

Greece and other smaller economies that are still recovering from the last recession will also be badly affected by the downturn. But heavy debt loads in many of these nations make them reluctant to amass yet more debt, and their budgets aren’t sufficient to self-fund their recoveries. That led them to turn to the European Union for help.

Together with the vast bond-buying program by the European Central Bank, national stimulus plans worth trillions of euros, and other, smaller E.U. support schemes for banks, businesses and workers, European leaders hope to reverse the recession in 2021 and spend their way into a rapid and powerful recovery.

They also agreed on Tuesday on the bloc’s regular budget for the next seven years: €1.1 trillion euros to finance the normal E.U. policies on agriculture, migration and hundreds of other programs.

But the deal came at a heavy price in progressive goals attached to E.U. values and norms. To bring Hungary and Poland on board, E.U. leaders decided to water down the caveat making funding conditional on the rule-of- law benchmarks that the two nations’ illiberal governments are violating.

In another concession to Poland, the bloc’s most coal-dependent nation, a requirement was dropped that would have committed the country to being carbon neutral by 2050 to draw on parts of the funds.

Since its inception, the E.U. has struggled between maintaining nation-state sovereignty and developing joint federal-style structures.

The deal reached on Tuesday is significant in that more creditworthy E.U. nations will be underwriting loans to fund the recoveries of countries that would otherwise face onerous borrowing costs.

The Netherlands and Austria were hostile to the very idea of borrowing money and simply giving much of it to benefit mostly southern, weaker economies.

Image

Credit…Pool photo by Francisco Seco

Under significant pressure at home as elections approach next March, the Dutch prime minister, Mr. Rutte, advocated loudly for fewer handouts to those nations, among them Italy and Spain, that have been hardest hit by the pandemic but that also have structurally weak, unreformed economies.

The Netherlands and other wealthier nations with healthier public finances are concerned that the commonly funded aid would simply go into a bottomless pit of spending that doesn’t truly help these economies recover without changes to make it easier to reduce bureaucracy, create jobs and stimulate growth.

A key argument in favor of offering grants rather than loans has been that Italy and other countries likely to take the aid are already over-indebted, and piling on yet more loans would just worsen their positions.

Mr. Rutte fought successfully for bigger-than-usual rebates, or reimbursements, for his own and other nations that are net contributors to the E.U. budget.

He and the others succeeded in wringing out another concession: Any country that wishes to use the new funds will need to submit a plan for how it intends to spend the money. The other E.U. nations will have a chance to review and object to the plan within three days of its submission and demand that it be tweaked.

Still, that mechanism fell short of the outright veto that Mr. Rutte had demanded, which the Italian and Spanish leaders denounced as an unacceptable encroachment into their authority.

The package will go to the European Parliament for ratification, and is expected to face a serious challenge on the grounds that it does not tackle concerns about how Poland and Hungary’s governments violate the bloc’s standards for democracy and the rule of law.

Monika Pronczuk contributed reporting.

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Groundbreaking: Scientists create an air filter that kills the coronavirus https://virusreports.net/groundbreaking-scientists-create-an-air-filter-that-kills-the-coronavirus/ https://virusreports.net/groundbreaking-scientists-create-an-air-filter-that-kills-the-coronavirus/#respond Mon, 13 Jul 2020 23:21:07 +0000 https://virusreports.net/groundbreaking-scientists-create-an-air-filter-that-kills-the-coronavirus/ The coronavirus is spurring on all kinds of innovation and creativity from the scientific community as well as the business community. The main focus now is on developing a vaccine and therapeutic drugs to combat the virus. Businesses have shut down normal production of products and switched to manufacturing essential medical equipment, like ventilators, as…

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The coronavirus is spurring on all kinds of innovation and creativity from the scientific community as well as the business community. The main focus now is on developing a vaccine and therapeutic drugs to combat the virus. Businesses have shut down normal production of products and switched to manufacturing essential medical equipment, like ventilators, as well as personal protection equipment to meet the needs of hospitals and first responders. All of this is good.

Meanwhile, researchers at the University of Houston (UH) have developed an air filter that kills the coronavirus. It is a “catch and kill” filter and it sounds really promising. It traps the virus and other pathogens and instantly kills them. The researchers teamed up with others to make it happen. Zhifeng Ren, director of the Texas Center for Superconductivity at UH and Monzer Hourani, CEO of Medistar, a Houston-based medical real estate development firm, as well as other researchers, came together to design the filter. With just one pass through the filter, 99.8% of the germs were killed.

The researchers reported that virus tests at the Galveston National Laboratory found 99.8% of the novel SARS-CoV-2, the virus that causes COVID-19, was killed in a single pass through a filter made from commercially available nickel foam heated to 200 degrees Centigrade, or about 392 degrees Fahrenheit. It also killed 99.9% of the anthrax spores in testing at the national lab, which is run by the University of Texas Medical Branch.

Think of the possible uses for this filter. Schools, for instance, could more safely re-open if classrooms had these filters. Other places that Ren, MD Anderson Chair Professor of Physics at UH and the co-corresponding author for the paper published in Materials Today Physics, suggests are airports, airplanes, and cruise ships. Medistar executives also suggest building a desktop model to purify the air in an office worker’s immediate area.

Medistar approached the Texas Center for Superconductivity at the University of Houston in March for help in developing the filter. We know the virus is an airborne one that can potentially linger in the air for up to three hours. The filter can certainly act as a tool to mitigate the spread of the coronavirus in places where social distancing may not be very practical.

Researchers knew the virus doesn’t hold up in the heat – nothing above about 158 degrees Fahrenheit (70 degrees Centigrade) – so they decided to use a heated filter. They wanted to make the filter temperature hotter, at least 200 degrees Centigrade to instantly kill the germs. At first, they used nickel foam, then adjustments had to be made.

But nickel foam has low resistivity, making it difficult to raise the temperature high enough to quickly kill the virus. The researchers solved that problem by folding the foam, connecting multiple compartments with electrical wires to increase the resistance high enough to raise the temperature as high as 250 degrees C.

By making the filter electrically heated, rather than heating it from an external source, the researchers said they minimized the amount of heat that escaped from the filter, allowing air conditioning to function with minimal strain.

A prototype was built by a local workshop and first tested at Ren’s lab for the relationship between voltage/current and temperature; it then went to the Galveston lab to be tested for its ability to kill the virus. Ren said it satisfies the requirements for conventional heating, ventilation and air conditioning (HVAC) systems.

The part about heating up and interfering with air conditioning systems was what my concern was when I first read about it. In this part of the country, air conditioning is essential, and believe me, no one wants anything to interfere with it.

A phased-in rollout of the filter is called for by the creators. It makes sense that workers at elevated risk should get the filter first – hospital workers, health care facilities, schools, even public transportation environments like airplanes. These filters can allow workers additional protection from the germs that infect them with the virus and also allow people and school kids to get back to work and classes safely.

Protection from the airborne germs is even more important than hand washing and social distancing according to many scientists who are now asking the WHO and other public health organizations to adjust guidelines to emphasize the risk.

“Respiratory droplets are very large droplets that when you sneeze, for example, they shoot out of your mouth and they drop right to the ground because of gravity,” Dr. Ron Elfenbein, an emergency care physician, explained Monday on CBSN. “Whereas airborne means that the virus can hang out in the air for a long time and all you have to do is walk by a cloud of this and inhale it and you’re going to catch it.”

The smaller particles could spread by infected individuals simply breathing, laughing or talking, said Elfenbein, who said he agrees with the scientists behind the letter.

In some cases, those tiny particles called aerosols can travel up to 30 feet, and there’s concern they may play a significant role in the spread of COVID-19.

The scientists can argue among themselves how far the particles travel in the air but social distancing at six feet apart is difficult enough, 30 feet is impossibly impractical. The advice and guidelines continue to shift as scientists continue to learn more about the coronavirus. It’s frustrating and confusing to most of us how little the experts still know about the virus. This new filter is really encouraging, though, and sounds like it could be a real help in containing the spread of coronavirus germs.

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