Chloroquine

SummaryBackgroundHydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit. Although generally safe when used for approved indications such as autoimmune disease or malaria, the safety and benefit of these treatment regimens are poorly evaluated in COVID-19.MethodsWe did a multinational…

WASHINGTON — A top Health and Human Services official who said he was transferred from his post for pushing back on “efforts to fund potentially dangerous drugs promoted by those with political connections” felt pressured to rush access to chloroquine treatments for coronavirus after President Donald Trump had a conversation about it with a mega-rich…

In-vitro studies have shown that chloroquine is effective against several viruses, including severe acute respiratory syndrome coronavirus (SARS-CoV).1Savarino A Boelaert JR Cassone A Majori G Cauda R Effects of chloroquine on viral infections: an old drug against today's diseases?. Multiple mechanisms of action have been identified for chloroquine that disrupt the early stage of coronavirus…